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SIZEMORE, N., D.S. WRIGHT, W.T. MUELLER AND B.-S. KUO. Impact of receptor downregulation on clearance of two human EGFs with different receptor binding activity. PEPTIDES 17(7) 1229–1236, 1996.—Human epidermal growth factor [hEGF(1–53)] has been thought to be cleared mainly via an EGF receptor (EGFR) endocytosis pathway. Pretreatment of rats with hEGF(1–53) has been shown previously to cause a dramatic...
WAYNER, M.J., D.L. ARMSTRONG AND C.F. PHELIX. Nicotine blocks angiotensin II inhibition of LTP in the dentate gyrus. PEPTIDES 17(7) 1127–1133, 1996.—Angiotensin (ANG)-containing axons, terminals, and receptors have been found in the hippocampus. When angiotensin II (ANG II) is administered to the dentate gyrus, long-term potentiation (LTP) induction, in response to medial perforant path stimulation,...
LUCAS, G.A., L.R. WHITE, R. JUUL, J. CAPPELEN, J. AASLY AND L. EDVINSSON. Relaxation of human temporal artery by endothelin ETB receptors. PEPTIDES 17(7) 1139–1144, 1996.—Endothelin receptors have been characterized in human temporal artery by molecular biological methods and in vitro pharmacology. Reverse transcriptase-polymerase chain reaction was used to detect mRNA encoding ETA and ETB receptors...
DELBAERE, A., Y. ENGLERT, P.J.M. BERGMANN, E. DE PREZ, J.-M. GIOT AND M. DESCHODT-LANCKMAN. Bioactive angiotensin (1–8) is the main component of angiotensin II immunoreactivity in human follicular fluid. PEPTIDES 17(7) 1135–1138, 1996.—The ovarian renin-angiotensin system is involved in various aspects of human reproduction. As immunoreactive measurement of angiotensin II (ANG II) in follicular fluid...
RAYMOND, P., M. BOUVIER, G. DRAPEAU, C. BLAIS, JR., R. MORAIS AND A. ADAM. Bradykinin decreases T-kininogen synthesis in a rat hepatoma cell line: Evidence of bradykinin B2-type receptors. PEPTIDES 17(7) 1171–1176, 1996.—Using the rat H4-II-E-C3 hepatoma cell line, we investigated the presence of [125I][Tyr8]BK binding sites and the direct modulation of T-kininogen synthesis, an acute phase protein...
VAN BAEL, A., V. VANDE VIJVER, B. DEVREESE, J. VAN BEEUMEN AND C. DENEF. N-terminal 10- and 12-kDa POMC fragments stimulate differentiation of lactotrophs. PEPTIDES 17(7) 1219–1228, 1996.—Medium conditioned by a highly enriched population of gonadotrophs, cultured as reaggregates in the presence of 0.01 nM GnRH, was concentrated, separated on a reversed-phase HPLC column, and tested for activity on...
OVERTON, R.M. AND D.L. VESELY. Processing of long-acting natriuretic peptide and vessel dilator in human plasma and serum. PEPTIDES 17(7) 1155–1162, 1996.—High performance-gel permeation chromotography (HP-GPC) evaluation of human plasma and serum incubated at 37°C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase...
RAYMOND, P., A. DÉCARIE, F. LANTIN, R. RAUT, R. MORAIS, R. COUTURE AND A. ADAM. A role for B1 and B2 kinin receptors in the modulation of T-kininogen during the acute phase response of inflammation. PEPTIDES 17(7) 1163–1170, 1996.—Kinin antagonists at B1 and B2 receptors were examined on liver and serum concentrations of immunoreactive T-kininogen and its gene expression in a rat model of carrageenan-induced...
FEIGENBAUM, J.J., M.D. CHOUBAL, D.S. CRUMRINE AND J.R. KANOFSKY. Receptor inactivation by dye-neuropeptide conjugates: 2. Characterization of the quantum yield of singlet oxygen generated by irradiation of dye-neuropeptide conjugates. PEPTIDES 17(7) 1213–1217, 1996.—Different neuropeptide analogues of the neurotransmitter FMRFamide were covalently attached to a tethered dye, forming dye-neuropeptide...
PERRAS, B., M. MÖLLE, J. BORN AND H.L. FEHM. Sleep and signs of attention during 3 months of intranasal vasopressin: A pilot study in two elderly subjects. PEPTIDES 17[7]1253–1255, 1996.—Prominent features of aging include a decrease of attention abilities and loss of sleep. Although acute effects of vasopressin (VP) on these functions in the elderly remained inconsistent, beneficial effects of the...
RAO, J.N., L. DEBELJUK AND A. BARTKE. Effect of photoperiod on hypothalamic and anterior pituitary tachykinins of male Siberian hamsters during development. PEPTIDES 17(7) 1177–1181, 1996.—In previous reports from our laboratory we showed that the hypothalamus and especially the anterior pituitary gland of the Siberian hamster contain very high concentrations of substance P- and neurokinin A-like...
GUAN, J.-L., Q.-P. WANG AND Y. NAKAI. Synaptic innervation of enkephalinergic neurons by axon terminals immunoreactive to dopamine-β-hydroxylase in the rat area postrema. PEPTIDES 17(7) 1203–1206, 1996.—A preembedding double immunostaining technique was used to study synaptic relations between enkephalin-like immunoreactive and dopamine-β-hydroxylase-like immunoreactive neurons in the rat area postrema...
BALASUBRAMANIAM, A., W. ZHAI, Z. TAO, Y. HUANG, J.E. FISCHER, P. EDEN, J.E. TAYLOR, L. KAR, S.D. SAMARASINGHE AND M.E. JOHNSON. Synthesis, structure, and antagonistic properties of des-Asn29[d-Trp28,32]NPY(27–36). PEPTIDES 17[7]1113–1118, 1996.—We have previously reported that [d-Trp32]NPY and its centrally truncated analogues such as des-AA7-24[d-Trp5,32,Aoc6]NPY can competitively antagonize NPY...
HEIZMANN, J., P. LANGGUTH, A. BIBER, R. OSCHMANN, H.P. MERKLE AND S. WOLFFRAM. Enzymatic cleavage of thymopoietin oligopeptides by pancreatic and intestinal brush-border enzymes. PEPTIDES 17(7) 1083–1089, 1996.—The intestinal enzymatic degradation of the immunomodulating peptides thymotrinan (TP3), thymocartin (TP4), and thymopentin (TP5), three oligopeptides derived from the naturally occurring thymus...
MERALI, Z. AND H. PLAMONDON. Pharmaco-ontogenic modulation of feeding by oxytocin, bombesin, and their antagonists. PEPTIDES 17(7) 1119–1126, 1996.—Oxytocin (OX) and bombesin (BN) can both suppress food intake in adult rats. In light of important transient fluctuations in peptide and/or receptor expression early after birth, this study characterized the feeding-suppressant effects of OX and BN during...
TAYLOR, J.E., R. NELSON AND C.-W. WOON. Real-time evaluation of somatostatin subtype 2 receptor activity employing the technique of cytosensor microphysiometry. PEPTIDES 17(7) 1257–1259, 1996.—Five types of somatostatin (SS) receptors (sst1−5) have been cloned and are widely distributed in the central nervous system and variably expressed in target tissues of the periphery. At the cellular level,...
YAMAGUCHI, M. AND T. MATSUI. Stimulatory effect of zinc-chelating dipeptide on deoxyribonucleic acid synthesis in osteoblastic MC3T3-E1 cells. PEPTIDES 17(7) 1207–1211, 1996.—Whether deoxyribonucleic acid (DNA) synthesis in osteoblastic MC3T3-E1 cells is stimulated by zinc, an activator of bone formation, was investigated in vitro. After subculture for 3 days, the cells were cultured for up to 3 days...
BARR, C.S., P. RHODES AND A.D. STRUTHERS. C-type natriuretic peptide. PEPTIDES 17(7) 1243–1251, 1996.—C-type natriuretic peptide is a 22-amino acid peptide that was initially identified in the central nervous system. The distribution of C-type natriuretic peptide, which has structural homology with atrial and brain natriuretic peptides, is wide and includes the endothelium, myocardium, gastrointestinal,...
ALCALDE, A.I., M.A. PLAZA AND R. MARCO. Study of the binding of motilin to the membranes of enterocytes from rabbit jejunum. PEPTIDES 17(7) 1237–1241, 1996.—The results obtained in the present work have shown that [125I]motilin bound specifically to basolateral (BL) membrane but it did not bind to the brush border (BB) membrane of the rabbit jejunum enterocyte. The [125I]motilin dissociation constant...
LEONDIADIS, L., E. LIVANIOU, I. VASSILIADOU, N. FERDERIGOS, D.S. ITHAKISSIOS AND G.P. EVANGELATOS. Development of specific anti-thymosin β10 antipeptide antibodies for application in immunochemical techniques. PEPTIDES 17(7) 1091–1096, 1996.—We present theoretical and experimental data necessary for raising specific antibodies for thymosin β10, a 43-amino acid residues peptide occurring in human tissues...
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